Pruritus Ani is so common today that it is known as the "Space-age" disease. Occasionally, pinworms, lice, fungus, and hemorrhoids maybe responsible. Rarely, food allergies, and allergies to drugs such as antibiotics may be the cause. Pruritus ani is also associated with certain systemic disorders such as jaundice, diabetes, lymphoma, and uremia. Pruritus ani is a self-perpetuating disease: scratching causes further irritation, which becomes a new source of itching. The cause of pruritis ani may be difficult to determine, thus making pruritis ani a potentially difficult conditions to treat.

Signs and symptoms: Itching, particularly at night. Skin changes occur which are due in part to scratching hyperemia, excoriations, abrasions, thickening, and lichenification.